Multifunctional theragnostic ultrasmall gold nanodot-encapsuled perfluorocarbon nanodroplets for laser-focused ultrasound sequence irradiation (LFSI)-based enhanced tumor ablation.
Menghan XuWei LongXiang LingXiongwei HuHao HongYayun PengTing CaiPublished in: Journal of materials chemistry. B (2022)
Despite the substantial potential of focused ultrasound therapy, its efficacy in cancer therapy has been limited due to the high cavitation threshold and safety concerns regarding the use of high-intensity energy pulses. Here, ultrasmall Au nanodot-loaded PEG-modified perfluorocarbon nanodroplets (Au-PFCnDs) were prepared and used as a therapeutic enhancer. A LFSI method was designed to achieve enhanced tumor ablation at a mild focused ultrasound (FUS) energy pulse with the assistance of the instinct photothermal effect of intratumor-permeable ultrasmall Au nanodots under 808 nm NIR laser irradiation. In addition to their therapeutic function, Au-PFCnDs can also generate multimodal images to provide information for tumor surveillance and treatment guidance. The experimental results also showed that the cRGD-targeted Au-PFCnDs could be more efficiently delivered into the tumor and selectively destroy tumors with no observable side effects on normal tissue under LFSI treatment.
Keyphrases
- cancer therapy
- drug delivery
- high intensity
- sensitive detection
- reduced graphene oxide
- photodynamic therapy
- public health
- stem cells
- deep learning
- transcription factor
- optical coherence tomography
- radiation induced
- radiation therapy
- drug release
- mesenchymal stem cells
- machine learning
- health information
- iron oxide
- fluorescence imaging
- social media
- amino acid
- wound healing
- smoking cessation
- metal organic framework