ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms.

Jody Fromm LongoStephanie N BrosiusLaurel BlackStuart H WorleyRobert C WilsonKevin A RothSteven L Carroll

Published in: Cell communication and signaling : CCS (2019)

ErbB4 promotes MPNST growth by activating key non-Ras dependent signaling cascades including the STAT3, STAT5 and phospholipase-Cγ pathways. ErbB4 and its effector pathways are thus potentially useful therapeutic targets in MPNSTs.

Keyphrases

peripheral nerve
tyrosine kinase
cell proliferation
wild type
signaling pathway
dendritic cells
immune response