Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3.

Masahiro MaedaHideyuki TakeshimaNaoko IidaNaoko HattoriSatoshi YamashitaHiroshi MoroYoshimi YasukawaKazuhiro NishiyamaTaiki HashimotoShigeki SekineGenichiro IshiiAtsushi OchiaiTakeo FukagawaHitoshi KataiYoshiharu SakaiToshikazu Ushijima

Published in: Gut (2019)

H3K27me3 plays a crucial role in defining tumour-promoting capacities of CAFs, and multiple stem cell niche factors were secreted from CAFs due to loss of H3K27me3. The validity of the epigenetic approach to uncover therapeutic targets for cancer-starving therapy was demonstrated.

Keyphrases

stem cells
papillary thyroid
dna methylation
gene expression
squamous cell carcinoma
young adults
bone marrow