Increased IGFBP Proteolysis, IGF-I Bioavailability, and Pappalysin Levels in Children With Prader-Willi Syndrome.

Vicente Barrios-Sabador Álvaro Martín-Rivada Gabriel Ángel Martos-Moreno Sandra Canelles Francisca Moreno-MaciánCarmen De Mingo-AlemanyMaurizio DelvecchioRoberta PajnoDanilo Fintini Julia A Chowen Jesús Argente

Published in: The Journal of clinical endocrinology and metabolism (2024)

The increase in PAPP-A could be involved in increased IGFBP proteolysis, promoting IGF-I bioavailability in children with PWS. Further studies are needed to establish the relationship between growth, GH resistance, and changes in the IGF axis during development and after GH treatment in these patients.

Keyphrases

growth hormone
end stage renal disease
young adults
ejection fraction
newly diagnosed
chronic kidney disease
pi k akt
binding protein
peritoneal dialysis
patient reported outcomes
signaling pathway