Ectopically expressed Airn lncRNA deposits Polycomb with a potency that rivals Xist .

Jackson B TrotmanAki K BracerosSteven R BischoffMcKenzie M MurvinSamuel P BoysonRachel E CherneyQuinn E EberhardElizabeth W AbrashDale O CowleyJ Mauro Calabrese

Published in: bioRxiv : the preprint server for biology (2023)

We report that when expressed at similar levels from an isogenic locus, the Airn lncRNA induces Polycomb deposition with a potency that rivals Xist . However, when subject to the same degree of promoter activation, Xist is more abundant and more potent than Airn . Our data definitively demonstrate that the Airn lncRNA is functional and suggest that Xist achieved extreme potency in part by evolving mechanisms to promote its own abundance.

Keyphrases

long non coding rna
long noncoding rna
dna methylation
gene expression
transcription factor
electronic health record
machine learning
microbial community
artificial intelligence
data analysis
deep learning