GFR decline predicts total mortality and mediates the effect of tryptophan metabolism on death risk in type 2 diabetes.
Olga LamacchiaClaudia MenzaghiMassimiliano CopettiMario MastroiannoChiara CorsanoCornelia PrehnJerzy AdamskiAndrea FontanaVincenzo TrischittaSalvatore De CosmoPublished in: The Journal of clinical endocrinology and metabolism (2024)
In patients with type 2 diabetes, eGFR decline is independently associated with the risk of all-cause mortality and mediates a significant proportion of the association between tryptophan metabolism and death.