TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.

Yawen TangSajesan AryalXiaoxiao GengXinyue ZhouVladimir G FastJianyi Jay Zhang Rui Lu Yang Zhou

Published in: Circulation (2022)

TBX20 consolidates MGT cardiac reprogramming factors to activate cardiac enhancers to promote cardiac cell fate conversion. Human induced cardiomyocytes generated with TBX20 showed enhanced cardiac function in contractility and mitochondrial respiration.

Keyphrases

endothelial cells
left ventricular
high glucose
cell fate
induced pluripotent stem cells
oxidative stress
heart failure
atrial fibrillation