Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children.
Ricardo da Silva AntunesAaron SutherlandApril FrazierVeronique SchultenAnna PomésJill GlesnerAgustin CalatroniMatthew C AltmanRobert A WoodGeorge T O'ConnorJacqueline A PongracicGurjit K Khurana HersheyCarolyn M KercsmarRebecca S GruchallaMichelle GillAndrew H LiuEdward ZorattiMeyer KattanPaula J BusseLeonard B BacharierStephen J TeachLisa M WheatleyAlkis TogiasWilliam W BusseDaniel J JacksonAlessandro SettePublished in: Clinical and translational allergy (2021)
Our results demonstrate that in children with mild-to-moderate asthma, CR-specific T cell responses display a wide range of magnitude, allergen dominance, and polarization. These results will enable examination of whether any of the variables measured are affected by IT and/or are predictive of clinical outcomes.