Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity.

Marc PfefferléIrina L DubachRaphael M BuzziElena DürstNadja Schulthess-LutzLivio BaselgiaKerstin HansenLarissa ImhofSandra KoernigDidier Le RoyThierry RogerRok HumarDominik J SchaerFlorence Vallelian

Published in: Journal for immunotherapy of cancer (2023)

Our study offers a targeted approach to uncouple CD40-augmented antitumor immunity in peripheral tissues from harmful inflammatoxicity in the liver.

Keyphrases

induced apoptosis
cell cycle arrest
gene expression
high glucose
diabetic rats
nk cells
endothelial cells
cell proliferation