Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation.
Eduard JirkovskyAnna JirkovskáHana Bavlovič PiskáčkováVeronika SkalickáZuzana PokornáGalina KarabanovichPetra Kollárová-BrázdováJan KubešOlga Lenčová-PopelováYvona MazurováMichaela AdamcováAlexander R LyonJaroslav RohTomáš ŠimůnekMartin SterbaPublished in: Circulation. Heart failure (2021)
This study strongly supports a new mechanistic paradigm that attributes clinically effective cardioprotection against anthracycline cardiotoxicity to interactions with TOP2B but not metal chelation and protection against direct oxidative damage.
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