Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID-19-infected autopsy case.
Akiko TamuraRyosuke ImaiYutaka TomishimaNaoki NishimuraPublished in: Respirology case reports (2022)
We encountered a patient with severe coronavirus disease 2019 (COVID-19)-related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over-activated immune responses against COVID-19 infection. When COVID-19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset.
Keyphrases
- coronavirus disease
- acute respiratory distress syndrome
- mechanical ventilation
- pulmonary fibrosis
- extracorporeal membrane oxygenation
- sars cov
- ms ms
- respiratory failure
- multiple sclerosis
- immune response
- intensive care unit
- simultaneous determination
- respiratory syndrome coronavirus
- low grade
- oxidative stress
- case report
- mass spectrometry
- high grade
- drug induced
- cell wall