A Fatal Case of Life-Threatening Interstitial Pneumonitis Induced by Everolimus for Metastatic Renal Cell Carcinoma: A Comment about the Increased Risk of Interstitial Lung Disease in Japanese.
Yasukiyo MurakamiTetsuo FujitaYoji WakatabeMasatsugu IwamuraPublished in: Case reports in urology (2019)
We describe an 81-year-old woman with metastatic renal cell carcinoma who did not recover from life-threatening interstitial pneumonitis induced by everolimus therapy. She received everolimus due to disease progression after sunitinib, but 2 months after starting everolimus treatment, she visited the emergency department after developing a sudden fever and dyspnea. Chest CT revealed diffuse ground-glass opacities, thickening of the interlobular septa, and consolidation throughout both lung fields. The diagnosis was surmised to be everolimus-induced interstitial pneumonitis. Everolimus administration was stopped and 3 courses of steroid pulse therapy were administered, along with intensive care, but the patient died due to rapid respiratory failure.
Keyphrases
- metastatic renal cell carcinoma
- interstitial lung disease
- systemic sclerosis
- emergency department
- respiratory failure
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- blood pressure
- magnetic resonance imaging
- magnetic resonance
- mechanical ventilation
- mesenchymal stem cells
- contrast enhanced
- low grade
- bone marrow
- drug induced
- combination therapy
- image quality
- palliative care
- high grade
- renal cell carcinoma