SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation.

Shiyu ZhangXing JiaHaojiang DaiXingxin ZhuWenfeng SongSuchen BianHao WuShinuo ChenYangbo TangJunran ChenCheng JinMengqiao ZhouHaiyang XieShushen Zhen Penghong Song

Published in: Cancer communications (London, England) (2024)

SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c-Cbl-mediated ubiquitination, suggesting that inhibition of the SERPINE2-EGFR axis may be a potential target for liver cancer treatment.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
signaling pathway
risk assessment
climate change