Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model.
L Leonie van LeeuwenMitchel J R RuigrokBenedikt M KesslerHenri G D LeuveninkEmilia GorePublished in: British journal of pharmacology (2023)
Our findings demonstrate the value of using machine perfusion for administering anti- fibrotic drugs, such as galunisertib, proving it to be an effective example of repurposing.