Utilising multi-large omics data to elucidate biological mechanisms within multiple sclerosis genetic susceptibility loci.

Yuan ZhouGabriel Cuellar-PartidaSteve Simpson YapXin LinSuzi ClaflinKathryn BurdonJac CharlesworthBruce Taylor

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

We provide in silico evidence for the putative biological mechanisms by which the identified DNA methylation sites and target genes are functionally relevant to MS development in different tissues. Future research targeting these genes and DNA methylation sites will determine their roles in the pathophysiology of MS.

Keyphrases

genome wide
dna methylation
multiple sclerosis
gene expression
mass spectrometry
copy number
ms ms
white matter
molecular docking
electronic health record
single cell
cancer therapy
big data
drug delivery
transcription factor
bioinformatics analysis
deep learning
artificial intelligence