Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.
Chunhua XuLi WangYu ZhangWenling LiJinhong LiYang WangChenling MengJinzhong QinZhi-Hua ZhengHui Yao LanKingston King-Lun MakYu HuangYin XiaPublished in: Journal of the American Society of Nephrology : JASN (2020)
Our findings show that tubular Mst1/Mst2 deficiency leads to CKD through both the YAP and non-YAP pathways and that tubular YAP activation induces renal fibrosis. The pathogenesis seems to involve the reciprocal stimulation of TNF-α and YAP signaling activities.