Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics.

Muriel EatonZhefu QueJingliang ZhangKaethe BeckRiyi ShiJeff McDermottMichael LadischYang Yang

Published in: Pharmaceutical research (2021)

Increased activity/firing of DRG sensory neurons has been suggested as a key feature underlying nociception. Our results support the utility of an in vitro MEA assay with cultured DRG sensory neurons to probe the nociceptive potential of clinically relevant buffer components used in injectable biologics.

Keyphrases

spinal cord
high throughput
neuropathic pain
hyaluronic acid
machine learning
deep learning
high resolution
spinal cord injury
tissue engineering
living cells
human health
neural network