Integration of network pharmacology, UHPLC-Q exactive orbitrap HRMS technique and metabolomics to elucidate the active ingredients and mechanisms of compound danshen pills in treating hypercholesterolemic rats.
Shanlan LiJin AnTong ZhangGuangyun ChenZixuan ZhangZhuoqian GuoZiqi DaiXuehao ChengSijin ChengXiaomin XiongNan WangGuanghui JiangBing XuHaimin LeiPublished in: Journal of ethnopharmacology (2024)
CDP and Sa B have been shown to alleviate high-fat diet-induced hypercholesterolemia by activating the PPAR pathway and improving hepatic lipid metabolism. Our study demonstrated, for the first time, the complex mechanism of CDP, Sa B in the treatment of hypercholesterolemia at the protein and metabolic levels and provided a new reference that could elucidate the pharmacological effects of traditional Chinese medicine on hypercholesterolemia from multiple perspectives.
Keyphrases
- high fat diet induced
- high resolution mass spectrometry
- insulin resistance
- mass spectrometry
- cardiovascular events
- ultra high performance liquid chromatography
- liquid chromatography
- tandem mass spectrometry
- ms ms
- low density lipoprotein
- signaling pathway
- high resolution
- type diabetes
- cardiovascular disease
- adipose tissue
- metabolic syndrome
- protein protein
- smoking cessation
- network analysis