Risk of antibiotic treatment failure in premenopausal women with uncomplicated urinary tract infection.
Anne M ButlerMichael J DurkinMatthew R KellerYinjiao MaVikas R DharnidharkaWilliam G PowderlyMargaret A OlsenPublished in: Pharmacoepidemiology and drug safety (2021)
The risk of treatment failure differed by antibiotic agent, with higher risk associated with TMP/SMX versus nitrofurantoin, and lower or similar risk associated with broad- versus narrow-spectrum β-lactams. Given serious safety warnings for fluoroquinolones, these results suggest that nitrofurantoin may be preferable as the first-line agent for outpatient treatment of uncomplicated UTI.