MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation.

Huan LiuHuijuan KuangYiru WangLili BaoWanxin CaoLu YuMeihao QiRenfeng WangXiaoshan YangQingyuan YeFeng DingLili RenSiying LiuFurong MaShiyu Liu

Published in: Biological research (2024)

In summary, our findings reveal the otoprotective capacity of exogenous exosome-mediated autophagy activation in hair cells in an endocytosis-dependent manner, suggesting possibilities for deafness treatment.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
cell death
cell cycle arrest
signaling pathway
diabetic rats
stem cells
mesenchymal stem cells
high glucose
genome wide
working memory
gene expression
drug induced
pi k akt
endothelial cells
dna methylation