The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.

Tong ZhengBeilei ShenYu BaiEntao LiXun ZhangYong HuTing GaoQincai DongLin ZhuRui JinHui ShiHainan Liu Yuwei Gao Xuan Liu Cheng Cao

Published in: Journal of virology (2024)

. Notably, the IC50 of CREB1 inhibitor 666-15 is comparable to that of remdesivir. These results may extend to all highly pathogenic coronaviruses due to the conserved nsp13 sequences in the virus.

Keyphrases

sars cov
respiratory syndrome coronavirus
signaling pathway
transcription factor
disease virus