TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.

Kyung Min KimGi Don YooWoong HeoHo Taek OhJeekeon ParkSomin ShinYoujin DoMi Gyeong JeongEun Sook HwangJeong-Ho Hong

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our results demonstrate a novel mechanism of TAZ-induced satellite cell activation after muscle injury and exercise, suggesting that activation of TAZ in satellite cells may ameliorate the muscle ageing phenotype and may be an important target protein for the drug development in sarcopenia.

Keyphrases

skeletal muscle
single cell
cell therapy
induced apoptosis
physical activity
high glucose
cell cycle arrest
high intensity
stem cells
diabetic rats
mesenchymal stem cells
cell proliferation
cell death
small molecule
bone marrow
protein protein
stress induced