DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma.

Katharina FilipskiMichael SchererKim N ZeinerAndreas BucherJohannes KleemannPhilipp JurmeisterTabea I HartungMarkus MeissnerKarl H PlateTim R FentonJörn WalterSascha TierlingBastian Schilling Pia S ZeinerPatrick N Harter

Published in: Journal for immunotherapy of cancer (2022)

These results demonstrate that LMC-based segregation of large-scale DNA methylation data is a promising tool for classifier development and treatment response estimation in cancer patients under targeted immunotherapy.

Keyphrases

dna methylation
genome wide
gene expression
electronic health record
big data
copy number
deep learning