Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions.

Albina WaithakaOlena MaiakovskaDirk GrimmLarissa Melo do NascimentoChristine Clayton

Published in: PLoS neglected tropical diseases (2022)

Our selectable constructs are suitable for screens of both sequences, and proteins that affect mRNA processing in T. brucei. Our results suggest that the functions of PTB and SR-domain proteins in splice site definition may already have been present in the last eukaryotic common ancestor.

Keyphrases

genome wide
binding protein
high throughput
dna methylation
protein protein
small molecule
single cell