Transforming Growth Factor-β1 in predicting early lung fibroproliferation in patients with acute respiratory distress syndrome.

Jean-Marie ForelChristophe GuervillyCatherine FarnarierStéphane-Yannis DonatiSami HraiechNicolas PersicoJérôme Allardet-ServentBenjamin CoiffardMarc GainnierAnderson LoundouAude SylvestreAntoine RochJeremy BourenneLaurent Papazian

Published in: PloS one (2018)

Pulmonary levels of TGF-β1 during the first week of ARDS were not associated nor with the presence of fibroproliferation neither with death. TGF-β1 should not be used as a biomarker to direct anti-fibrotic therapies.

Keyphrases

transforming growth factor
acute respiratory distress syndrome
extracorporeal membrane oxygenation
epithelial mesenchymal transition
mechanical ventilation
pulmonary hypertension
idiopathic pulmonary fibrosis
clinical trial
signaling pathway
placebo controlled
double blind