Chaperones in Neurodegeneration.
Iris LindbergJames ShorterR Luke WisemanFabrizio ChitiChad A DickeyPamela J McLeanPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Aberrant protein homeostasis within neurons results in protein misfolding and aggregation. In this review, we discuss specific roles for protein chaperones in the oligomerization, assembly, and disaggregation of proteins known to be abnormally folded in neurodegenerative disease. Collectively, our goal is to identify therapeutic mechanisms to reduce the cellular toxicity of abnormal aggregates.