Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.
Brandon ChalazanDenada PalmArvind SridharChristina LeeMaria ArgosMartha DaviglusJalees RehmanSreenivas KondaDawood DarbarPublished in: PloS one (2021)
We show that candidate SNPs in the FTO and TUB genes are associated with obesity in African Americans and Hispanic/Latinos individuals respectively. While the underlying pathophysiological mechanisms by which common genetic variants cause obesity remain unclear, we have identified novel therapeutic targets across racial and ethnic groups.