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Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.

Brandon ChalazanDenada PalmArvind SridharChristina LeeMaria ArgosMartha DaviglusJalees RehmanSreenivas KondaDawood Darbar
Published in: PloS one (2021)
We show that candidate SNPs in the FTO and TUB genes are associated with obesity in African Americans and Hispanic/Latinos individuals respectively. While the underlying pathophysiological mechanisms by which common genetic variants cause obesity remain unclear, we have identified novel therapeutic targets across racial and ethnic groups.
Keyphrases
  • african american
  • insulin resistance
  • metabolic syndrome
  • weight loss
  • type diabetes
  • high fat diet induced
  • weight gain
  • genome wide
  • adipose tissue
  • dna methylation
  • physical activity
  • transcription factor