A novel bis-triazole scaffold accessed via two tandem [3 + 2] cycloaddition events including an uncatalyzed, room temperature azide-alkyne click reaction.
Ksenia MalkovaAndrey BubyrevVasilisa KrivovichevaDmitry V Dar'inAlexander S BunevMikhail Yu KrasavinPublished in: Beilstein journal of organic chemistry (2022)
The previously described α-acetyl-α-diazomethanesulfonamide was employed in a three-component reaction with azide-containing benzaldehydes and propargylamines. Besides the initial formation of the triazole core, the reaction proceeded further, in uncatalyzed fashion at room temperature and yielded, after intramolecular azide-alkyne click reaction novel, structurally intriguing bistriazoles.