An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells.

Sheena C KerrJeanmarie R GonzalezJulia SchaninMichael C PetersBart N LambrechtEmily C BrockAnnabelle CharbitK M AnselBradford A YoungbloodJohn V Fahy

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Siglec-8 is highly expressed on eosinophils and mast cells in asthmatic sputum and targeting Siglec-8 with an antibody is a plausible strategy to decrease sputum eosinophils and inhibit lung mast cells in asthma.

Keyphrases

cystic fibrosis
lung function
pulmonary tuberculosis
mycobacterium tuberculosis
chronic obstructive pulmonary disease
cancer therapy
air pollution
allergic rhinitis