Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis.
Erin S BeckW Andrew MullinsJonadab Dos Santos SilvaStefano FilippiniPrasanna ParvathaneniJosefina MaranzanoMark MorrisonDaniel J SutoCorinne DonnayHenry DieckhausNicholas J LucianoKanika SharmaMaría Ines GaitánJiaen LiuJacco Adrianus de ZwartPeter van GelderenIrene CorteseSridar NarayananJeff H DuynGovind NairPascal SatiDaniel S ReichPublished in: medRxiv : the preprint server for health sciences (2023)
CL formation is rare in people with stable WML, even in those with worsening disability. CL but not WML burden predicts future worsening of disability, suggesting that the relationship between CL and disability progression is related to long-term effects of lesions that form in the earlier stages of disease, rather than to ongoing lesion formation.