Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade.
Andrew GeorgiadisJennifer N DurhamLaurel A KeeferBjarne R BartlettMagdalena ZielonkaDerek MurphyJames R WhiteSteve LuEllen L VernerFiney RuanDavid RileyRobert A AndersErika GedvilaiteSam AngiuoliSiân JonesVictor E VelculescuDung T LeLuis A DiazMark SausenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These analyses demonstrate the feasibility of noninvasive pan-cancer screening and monitoring of patients who exhibit MSI or TMB-High and have a high likelihood of responding to immune checkpoint blockade.See related commentary by Wang and Ajani, p. 6887.