Sustained pain hypersensitivity in the stressed colon: Role of mast cell-derived nerve growth factor-mediated enteric synaptic plasticity.

Lei ZhangJ SongT BaiR WangX Hou

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

In conclusion, mast cells/NGF pathway may be the key regulator of synaptic plasticity of ENS and participate in the formation of chronic stress-induced sustained visceral hypersensitivity.

Keyphrases

growth factor
stress induced
drug induced
chronic pain
pain management
neuropathic pain
insulin resistance
transcription factor
type diabetes
adipose tissue
metabolic syndrome
spinal cord