Groebke-Blackburn-Bienaymé Reaction for DNA-Encoded Library Technology.
Yujin AnJuyeon LeeHyewon SeoSeri BaeJihee KangJieon LeeJinwoo KimMyung Hee NamMinsoo SongGil Tae HwangPublished in: Organic letters (2023)
This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2- a ]pyridin-3-amine derivatives using the Suzuki-Miyaura reaction, followed by a Groebke-Blackburn-Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology.