Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease.
Mieradilijiang AbudupataerShichao ZhuShiqiang YanKehua XuJingjing ZhangShaman LuoWenrui MaMd Fazle AlamYuyi TangHui HuangNan ChenLi WangGuoquan YanJun LiHao LaiChunsheng WangKai ZhuWeijia ZhangPublished in: eLife (2021)
National Key R and D Program of China, National Natural Science Foundation of China, Shanghai Municipal Science and Technology Major Project, Shanghai Science and Technology Commission, and Shanghai Municipal Education Commission.
Keyphrases
- aortic valve
- quality improvement
- smooth muscle
- aortic stenosis
- public health
- transcatheter aortic valve replacement
- wastewater treatment
- transcatheter aortic valve implantation
- aortic aneurysm
- aortic valve replacement
- oxidative stress
- healthcare
- circulating tumor cells
- pulmonary hypertension
- heavy metals
- atrial fibrillation