The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Daniela Josabeth López-CanoDaniel Cadena-SandovalOlga Beltrán-RamírezRosa Elda Barbosa-CobosFausto Sánchez-MuñozLuis Manuel Amezcua-GuerraYaneli Juárez-VicuñaMaría Concepción Aguilera-CartasJosé MorenoJesús Bautista-OlveraGuillermo Valencia-PachecoRicardo F López-VillanuevaJulián Ramírez BelloPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)
Our data provide the first demonstration that PTPN22 R620W confers GD susceptibility among Latin-American patients. Moreover, this is the second report documenting the association of PTPN22 R263Q with protection against SLE and RA.