Independent of Primary Sclerosing Cholangitis and Cirrhosis, Early Adulthood Obesity is Associated with Cholangiocarcinoma.

Rikita I Hatia Madhulika Eluri Ernest T Hawk Akram Shalaby Elif Karatas Ahmed Shalaby Ahmed A Abdelhakeem Reham Abdel-Wahab Ping Chang Asif Rashid Prasun Kumar Jalal Christopher Ian Amos Younghun Han Tannaz Armaghany Rachna T Shroff Dounghui Li Milind M Javle Manal M Hassan

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

The study highlights the association between obesity and CCA, independent of PSC. There is a need to consider the mechanistic pathways of obesity in the absence of fatty liver and cirrhosis.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
depressive symptoms
body mass index
physical activity