Focused ultrasound blood-brain barrier disruption in high-grade gliomas: Scoping review of clinical studies.

Seyed Farzad MaroufiMohammad Sadegh FallahiSeyede Parmis MaroufiJason P Sheehan

Published in: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2024)

Studies investigating BBBD using FUS demonstrate promising outcomes in experimental and clinical settings. BBBD procedures in patients with malignant gliomas and recurrent GBM show safety and successful enhancement of drug delivery potential. Overall, FUS-mediated BBBD emerges as a safe and feasible approach for improving therapeutic outcomes in brain tumor patients, warranting further clinical exploration and optimization.

Keyphrases

high grade
blood brain barrier
drug delivery
low grade
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
cerebral ischemia
brain injury
cancer therapy
risk assessment
insulin resistance