Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review.
Giovanni AssenzaMario TombiniJacopo LanzoneLorenzo RicciVincenzo Di LazzaroSara CasciatoAlessandra MoranoAnna Teresa GiallonardoCarlo Di BonaventuraEttore BeghiEdoardo FerlazzoSara GaspariniLoretta GiulianoFrancesco PisaniPaolo BennaFrancesca BisulliFabrizio A De FalcoSilvana FranceschettiAngela La NeveStefano MelettiBarbara MostacciFerdinando SartucciPasquale StrianoFlavio VillaniUmberto AgugliaGiuliano AvanziniVincenzo BelcastroAmedeo BianchiVittoria CianciAngelo LabateAdriana MagauddaRoberto MichelucciAnnapia VerriGaetano ZaccaraVincenzo PizzaPaolo TinuperGiancarlo Di Gennaronull nullPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)
Reviewed studies strongly suggest that VNS ameliorates depressive symptoms in drug-resistant epileptic patients and that the VNS effect on depression is uncorrelated to seizure response. However, more rigorous studies addressing this issue are encouraged.