BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer.

Jian WangYingzhuo XuXinrui RaoRuiguang ZhangJing TangDan ZhangXiaohua JieKuikui ZhuXu WangYunhong XuSheng ZhangXiaorong DongTao ZhangKunyu YangShuangbing XuRui MengGang Wu

Published in: Clinical and translational medicine (2022)

The data showed that BRD4-targeted therapy synergized with chemoradiotherapy and anti-PD-1 antibody by boosting anti-tumour immunity in NSCLC.

Keyphrases

rectal cancer
locally advanced
small cell lung cancer
high glucose
diabetic rats
electronic health record
dendritic cells
squamous cell carcinoma
radiation therapy
big data
drug induced
oxidative stress
endothelial cells
machine learning
brain metastases