Method-dependent variation in TSH and FT4 reference intervals in pregnancy: A systematic review.
Onyebuchi E OkosiemeMedha AgrawalDanyal UsmanCarol EvansPublished in: Annals of clinical biochemistry (2021)
Our study confirms significant intra- and intermethod disparities in gestational thyroid hormone reference intervals. The relationship between pregnant and non-pregnant values is inconsistent and does not support the existing practice in many laboratories of extrapolating gestation references from non-pregnant values. Laboratories should invest in deriving method-specific gestation reference intervals for their population.