Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders.
Seyedeh Morvarid NeishabouriHamed ShooreiZahra BahroudiBashdar Mahmud HussenSeyedeh Fahimeh TalebiMohammad TaheriSeyed Abdulmajid AyatollahiPublished in: Biomolecules (2022)
Curcumin is a natural polyphenol with antioxidant, antibacterial, anti-cancer, and anti-inflammation effects. This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreases levels of reactive oxygen species and electrophilic substances. Nrf2-related effects of curcumin have been investigated in different contexts, including gastrointestinal disorders, ischemia-reperfusion injury, diabetes mellitus, nervous system diseases, renal diseases, pulmonary diseases, cardiovascular diseases as well as cancers. In the current review, we discuss the Nrf2-mediated therapeutic effects of curcumin in these conditions. The data reviewed in the current manuscript indicates curcumin as a potential activator of Nrf2 and a therapeutic substance for the protection of cells in several pathological conditions.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- induced apoptosis
- reactive oxygen species
- cardiovascular disease
- electronic health record
- metabolic syndrome
- machine learning
- signaling pathway
- skeletal muscle
- cell cycle arrest
- anti inflammatory
- drinking water
- cell proliferation
- immune response
- atomic force microscopy
- high resolution
- toll like receptor
- stress induced
- glycemic control