The Influence of Topically Administered Heparin on Peripheral Microcirculation of the Skin: A Double-Blind, Randomized, Controlled Preliminary Study on 50 Healthy Subjects.
Markus DenzingerManuel HeldAmro AmrSabrina KraußDominik BenderAdrien DaigelerAndrea WengerPublished in: Journal of reconstructive microsurgery (2021)
As a first important step in possible future implementing of heparin as a topical administration in flap surgery, our data-although not statistically significant-indicate that heparin can improve microcirculation (SO2, flow) in healthy subjects. Nevertheless, further research in subjects with impaired microcirculation is necessary.
Keyphrases
- venous thromboembolism
- growth factor
- minimally invasive
- soft tissue
- double blind
- wound healing
- open label
- electronic health record
- current status
- clinical trial
- phase iii
- big data
- placebo controlled
- machine learning
- phase ii
- surgical site infection
- acute coronary syndrome
- breast reconstruction
- percutaneous coronary intervention