Factor H preserves alternative complement function during ARDS, linked to improved survival.
William G BainMohammadreza TabarySara R MooreXiaojing AnGeorgios D KitsiosBryan J McVerryPrabir RayAnuradha RayRama K MallampalliViviana P FerreiraJanet S LeeSeyed Mehdi NouraiePublished in: ERJ open research (2023)
Relative factor H deficiency, higher Ba:B and C3a:C3 ratios and lower factor B and C3 levels suggest a subset of ARDS with complement factor exhaustion, impaired alternative pathway function, and increased mortality, that may be amenable to therapeutic targeting.