Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.

Guoxin ZhangLanxia MengZhihao WangQinyu PengGuiqin ChenJing XiongZhentao Zhang

Published in: Molecular neurodegeneration (2022)

These observations indicate that IAPP acts as a crucial mediator of tau pathology in AD, and provide a mechanistic explanation for the higher risk of AD in individuals with T2DM.

Keyphrases

cerebrospinal fluid
cognitive decline
type diabetes
adipose tissue
metabolic syndrome