Is early recurrence of hepatocellular carcinoma in HCV cirrhotic patients affected by treatment with direct-acting antivirals? A prospective multicentre study.
Giuseppe CabibboSalvatore PettaVincenza CalvarusoIrene CacciolaM R CannavòS MadoniaM DistefanoL LaroccaT PrestileoF TinèG BertinoL GiannitrapaniF BenantiA LicataI ScalisiG MazzolaF CartabellottaN AlessiM BarbàraM RusselloG ScifoG SquadritoG RaimondoAntonio CraxiVito Di MarcoCalogero Cammànull nullPublished in: Alimentary pharmacology & therapeutics (2017)
Probability of HCC early recurrence in patients who had HCC previously cured remains high, despite HCV eradication by DAAs. Risk was comparable but not higher to that reported in literature in DAA-untreated patients. Previous HCC recurrence and tumour size can be used to stratify the risk of HCC early recurrence. Further studies are needed to assess impact of DAAs on late recurrence and mortality.