Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis.
Dag LeonardElisabet SvenungssonJohanna DahlqvistAndrei AlexssonLisbeth ÄrlestigKimberly E TaylorJohanna K SandlingChristine BengtssonMartina FrodlundAndreas JönsenSusanna EketjällKerstin Jensen-UrstadIva GunnarssonChristopher SjöwallAnders A BengtssonMaija-Leena ElorantaAnn-Christine SyvänenSolbritt Rantapää-DahlqvistLindsey A CriswellLars RönnblomPublished in: Annals of the rheumatic diseases (2018)
The IL19 risk allele was associated with stroke/MI in SLE and RA, but not in the general population, indicating that shared immune pathways may be involved in the CVD pathogenesis in inflammatory rheumatic diseases.
Keyphrases
- rheumatoid arthritis
- disease activity
- cardiovascular disease
- copy number
- systemic lupus erythematosus
- ankylosing spondylitis
- atrial fibrillation
- genome wide
- oxidative stress
- interstitial lung disease
- type diabetes
- gene expression
- genome wide identification
- transcription factor
- cerebral ischemia
- coronary artery disease