Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission.

Mujing YangRong LaiShuzhen PengYun ChangXingli ZengDandan WangXiaoshun ZhouYong Shao

Published in: Chemical communications (Cambridge, England) (2023)

Heptad-interfaced G-quadruplexes (G4s), formed with GGA repeats located in the nuclear proto-oncogene c-myb promoter, can be selectively targeted by a prenylated flavonol of sophoflavescenol (Sop) with restriction of molecular rotation to trigger strong excited state intramolecular proton transfer (ESIPT) emission.

Keyphrases

fluorescent probe
transcription factor
dna methylation
gene expression
single molecule
solid state