Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies.
Yuze YuanNan RanLingxin XiongGuoqiang WangXuewa GuanZiyan WangYingqiao GuoZhiqiang PangKeyong FangJunying LuChao ZhangRuipeng ZhengJingtong ZhengJie MaFang WangPublished in: Journal of immunology research (2018)
Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.
Keyphrases
- metabolic syndrome
- insulin resistance
- weight loss
- high fat diet induced
- type diabetes
- chronic obstructive pulmonary disease
- weight gain
- lung function
- public health
- allergic rhinitis
- adipose tissue
- skeletal muscle
- transcription factor
- body mass index
- risk factors
- mass spectrometry
- air pollution
- cardiovascular risk factors
- drug induced
- risk assessment