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PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF.

Jiang LiXi LiangJing JiangLingling YangJiaojiao XinDongyan ShiYingyan LuJun LiKeke RenHozeifa Mohamed HassanJianing ZhangPengcheng ChenHeng YaoJiaqi LiTianzhou WuLinfeng JinPing YeTan LiHuafen ZhangSuwan SunBeibei GuoXingping ZhouQun CaiJiaxian ChenXiaowei XuJianrong HuangShaorui HaoJinqiu HeShaojie XinDi WangJonel TrebickaXin ChenJun Linull null
Published in: Gut (2021)
This study highlights immune-metabolism disorder triggered by HBV exacerbation as a potential mechanism of HBV-ACLF and may indicate a novel diagnostic and treatment target to reduce HBV-ACLF-related mortality.
Keyphrases
  • hepatitis b virus
  • liver failure
  • chronic obstructive pulmonary disease
  • genome wide
  • single cell
  • cardiovascular events
  • type diabetes
  • cardiovascular disease
  • dna methylation
  • gene expression
  • climate change