Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls.

Youngjune BhakYeonsu JeonSungwon JeonChanghan YoonMin KimAsta BlazyteYeonkyung KimYounghui KangChangjae KimSang Yeub LeeJang-Whan BaeWeon KimYeo Jin KimJungae ShimNayeong KimSung ChunByoung-Chul KimByung Chul KimSemin LeeJong BhakEun-Seok Shin

Published in: PloS one (2021)

The PRS using 265 early-onset AMI genomes showed improvement in the identification of patients in the Korean population and showed potential for genomic screening in early life to complement conventional risk prediction.

Keyphrases

early onset
acute myocardial infarction
end stage renal disease
late onset
newly diagnosed
ejection fraction
early life
chronic kidney disease
prognostic factors
peritoneal dialysis
left ventricular
coronary artery disease
gene expression
acute coronary syndrome
copy number
human health